|
Inclusion Criteria:
- Age – Up to 70 years old or younger (No age limit for eye and tissue donation)
- Brain death declaration by Govt. authorized neuro-clinicians.
Note: Two sets of brain death certification at 6 hours apart.Second set time considered the actual timing of declared
death
Exclusion
Criteria for Organ Donation:
Active infections (specific diagnoses)
I. Bacterial infection
-
Tuberculosis
- Gangrenous bowel or perforated bowel and/or intra-abdominal sepsis
II Viral infections
- HIV infection by serologic or molecular detection
- Rabies
- Reactive Hepatitis B Surface Antigen
- Retroviral infections including HTLV I/II
- Viral Encephalitis or Meningitis
- Active Herpes simplex, varicella zoster, or cytomegalovirus viremia or pneumonia
- Acute Epstein Barr Virus (mononucleosis)
- West Nile Virus infection
- SARS
III Fungal infections:
- Active infection with Cryptococcus, Aspergillus, Histoplasma, Coccidioides Active candidemia or invasive yeast infection
IV Parasites:
- Active infection with Trypanosoma cruzi (Chagas')
- Leishmania, Strongyloides, or Malaria (Plasmodium sp.)
V Prion:
- Creutzfeldt-Jacob Disease
VI Other Exclusions
- Aplastic Anemia
- Aplastic Anemia
- Agranulocytosis
- Extreme Immaturity (<500 grams or gestational age of <32 weeks)
- Current malignant neoplasms except :
- non-melanoma skin cancers such as basal cell and squamous cell cancer Primary CNS tumors without evident metastatic disease
- Previous malignant neoplasms with current evident metastatic disease
- A history of melanoma
- Hematologic malignancies: Leukemia, Hodgkin's Disease, Lymphoma, Multiple Myeloma
- Multi-system organ failure (MSOF) due to overwhelming sepsis or MSOF without sepsis defined as 3 or more systems in simultaneous failure for a period of 24 hours or more without response to treatment or resuscitation
- Active Fungal, Parasitic, viral, or Bacterial Meningitis or encephalitis
VII The following reversible causes of coma should have been excluded
when declaring brain death:
- Intoxication (Alcohol)
- Depressant Drugs
- Relaxants (Neuromuscular blocking agents)
- Primary hypothermia
- Hypovolaemic shock
- Metabolic or endocrine disorders
- Previous malignant neoplasms with current evident metastatic disease
References
- Fischer, S. A., Graham, M. B., Kuehnert, M. J., Kotton, C. N., Srinivasan, A., Marty, F. M., Comer, J. A., Guarner, J., Paddock, C. D., DeMeo, D. L., Shieh, W.-J., Erickson, B. R., Bandy, U., DeMaria, A. Jr., Davis, J. P., Delmonico, F. L., Pavlin, B., Likos, A., Vincent, M. J., Sealy, T. K., Goldsmith, C. S., Jernigan, D. B., Rollin, P. E., Packard, M. M., Patel, M., Rowland, C., Helfand, R. F., Nichol, S. T., Fishman, J. A., Ksiazek, T., Zaki, S. R., the LCMV in Transplant Recipients Investigation Te, (2006). Transmission of lymphocytic choriomeningitis virus by organ transplantation.. NEJM 354: 2235-2249 [Abstract] [Full Text]
- Cozzi, E., Bosio, E., Seveso, M., Vadori, M., Ancona, E. (2006). Xenotransplantation--current status and future perspectives.. Br Med Bull 75-76: 99-114 [Abstract] [Full Text]
- Solomon, T., Marston, D., Mallewa, M., Felton, T., Shaw, S., McElhinney, L. M, Das, K., Mansfield, K., Wainwright, J., Kwong, G. N. M., Fooks, A. R (2005). Paralytic rabies after a two week holiday in India. BMJ 331: 501-503 [Full Text]
- Roos, K. L. (2005). Viral Encephalitis Transmitted From Donor to Organ Recipients. JAMA 294: 488-489 [Full Text]
- Jenwitheesuk, E., Jackson, A. C., Lapierre, V., Tiberghien, P., Srinivasan, A., Kuehnert, M., Rupprecht, C. (2005). Transmission of Rabies from an Organ Donor. NEJM 352: 2551-2552 [Full Text]
- Burton, E. C., Burns, D. K., Opatowsky, M. J., El-Feky, W. H., Fischbach, B., Melton, L., Sanchez, E., Randall, H., Watkins, D. L., Chang, J., Klintmalm, G. (2005). Rabies Encephalomyelitis: Clinical, Neuroradiological, and Pathological Findings in 4 Transplant Recipients. Arch Neurol 62: 873-882 [Abstract] [Full Text]
- (2005). Rabies in Four Organ Transplant Recipients. JWatch Neurology 2005: 7-7 [Full Text]
- (2005). Rabies Transmission via Organ Transplantation. JWatch Infect. Diseases 2005: 3-3 [Full Text]
- http://www.medindia.net/tho/thoform61.asp
|
